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St. Luke’s Selects Cushman & Wakefield to Market Des Peres Hospital Campus in St. Louis

Bailey Webb • 7/31/2025
Campus Aerial st lukes.jpg ST. LOUIS, July 31, 2025 – Cushman & Wakefield announced today that locally based St. Luke’s Health Corp. has selected the firm to lead marketing efforts to sell its Des Peres Hospital Campus. 

Cushman & Wakefield’s Tripp Hardin, SIOR, Mike Hanrahan and Jack Gentile are representing the regional hospital system in the disposition of its Des Peres Hospital campus.  

Located at the northwest quadrant of Interstate 270 and Dougherty Ferry Road, with access to Dougherty Ferry Road and Des Peres Road, the 47.4-acre site includes a 228,889-square-foot, 142-bed hospital.  

St. Luke’s announced plans to close the hospital August 1. This closure will not impact St. Luke’s hospital in Chesterfield or its 30+ outpatient locations across the region. The site is zoned for residential usage, but future healthcare-related uses are also potentially allowable under a conditional use permit.  

“St. Luke’s Des Peres campus is a unique, high-value location with an extremely strong surrounding-demographic profile,” said Hardin, Cushman & Wakefield Executive Director. “It is a prime opportunity for high-end residential redevelopment, or a continuation of healthcare services.  

About St. Luke’s 
St. Luke’s Hospital is a nationally acclaimed independent non-profit located in Chesterfield, MO. Known for its exceptional quality and patient satisfaction, St. Luke's has consistently earned prestigious awards and accolades. The hospital holds the exclusive alliance provider status in the St. Louis market for the Cleveland Clinic Heart, Vascular, and Thoracic Institute, further solidifying its position as a leader in cardiovascular care. Since its establishment in 1866, St. Luke's has evolved from a single hospital location into an advanced network of care. Its 493-bed hospital in Chesterfield, MO, serves as a hub for its 60+ specialties and 30 locations throughout the greater St. Louis area. For more information, visit stlukes-stl.com.

About Cushman & Wakefield
Cushman & Wakefield (NYSE: CWK) is a leading global commercial real estate services firm for property owners and occupiers with approximately 52,000 employees in nearly 400 offices and 60 countries. In 2024, the firm reported revenue of $9.4 billion across its core service lines of Services, Leasing, Capital markets, and Valuation and other. Built around the belief that Better never settles, the firm receives numerous industry and business accolades for its award-winning culture.  For additional information, visit www.cushmanwakefield.com.

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